So, if we (myself and the owners of our sound company) can get our hands on a venue, we have some pretty definitive ideas on how we would run it and I don't mind sharing (in case you think any are applicable).
Of course for us, some of these would slide one direction or another in the case of a more "event" style space like we used to manage, versus a "hangout/bar" location.
We would primarily focus on the Wednesday - Saturday Evening crowds. No breakfast, brunch, or lunch bullshit.
(Because we have quality sound/lighting gear and know how to use it) we would use house sound and backline to speed up multi-band performance changes unless it was a regional or national act that had quality gear/rider/etc.
Wed nights would exclusively be Audition and Open Mics. The audience would understand, it would allow us some indication of a band's talent and how they are to work with.
Thursday nights would be genre nights, like Funk/Reggae/Jazz/Blues.... again... much of the crowd could be focused knowing that a certain style might draw really well one or two nights a month versus trying to keep a quaint niche club open all month with only a handful of fans. It's worked in our area where certain venues that book national acts have a reggae night, or something off the wall like Jake Cinninger from Umphry's McGee has an improv group for jazz/fusion jams.
Friday and nights would be well paid, well rehearsed local, regional, or smaller national acts on gas-stop type gap shows. If there is a gap in the schedule, it's filled with a DJ/House Party night which works well when you have a college near by.... not as well in a small rural town (which is why Karaoke has filled that gap in many cities).
Concentrating the talent and the support staff to certain days of the week allows more time for cleaning/lighting tests/or making the space available for rented gatherings..... or my personal preference.... a performance stage for local not-for-profit music schools or other performers who would be over-the-moon with a quality light and sound stage, but normally wouldn't be able to afford to rent a nice venue and/or hire a quality sound company. Why does a youth "school of rock" band need to play their crappy little practice amps for parents and grand parents... when a "real" stage performance might actually showcase what it is they've been trying to learn in a more impressive way to their parents in the community. That kind of local good will does more advertising for a venue and your standing in a community than flashy ads and donations ever can.